RNF111

GENOME
Homo sapiens (human)
CHROMOSOME
chr15
AVERAGE REVIEWED TARGET EFFICIENCY
N/A
REVIEWS
0

Gene Description

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]



POSITION
SEQUENCE
SCORE
# OF MISMATCHES
PRICE

We currently do not offer sgRNA-expressing DNA construct for this gene.

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Currently no Available sgRNA-expressing DNA Constructs