DNMT3B

GENOME
Homo sapiens (human)
CHROMOSOME
chr20
AVERAGE REVIEWED TARGET EFFICIENCY
N/A
REVIEWS
0

Gene Description

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]



POSITION
SEQUENCE
SCORE
# OF MISMATCHES
PRICE

We currently do not offer sgRNA-expressing DNA construct for this gene.

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Currently no Available sgRNA-expressing DNA Constructs